Polymorphismus (FGG 10034C>T)

Background

Thrombin-induced conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in the stabilization of thrombi. A C/T polymorphism at nucleotide 10034 of the fibrinogen gamma gene (FGG 10034C>T) leads to an alteration in the expression of fibrinogen gamma, without affecting total fibrinogen levels. This alteration results in an increased susceptibility to venous thrombosis.

Fibrinogen gamma (FGG 10034C>T) genotypes

Genotype	Frequency	Commentary
FGG 10034  CC	60%	Wild type genotype. No FGG 10034T variant present detectable.
FGG 10034  CT	35%	Heterozygous for the FGG 10034T variant. The risk for venous thrombosis is about 30% higher compared to the wild type genotype.
FGG 10034  TT	5%	Homozygous for the FGG 10034T variant. The risk of venous thrombosis is increased about 2-fold compared to the wild type genotype.

Indications for testing

Estimation of individual risk for venous thrombosis

Specimen Shipping

Literature:

Grünbacher G, Weger W, Marx-Neuhold E, Pilger E, Köppel H, Wascher T, März W, Renner W. The fibrinogen gamma (FGG) 10034C>T polymorphism is associated with venous thrombosis. Thromb Res. 2007;121:33-6.
Uitte de Willige S, de Visser MC, Houwing-Duistermaat JJ, Rosendaal FR, Vos HL, Bertina RM. Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen gamma' levels. Blood. 2005;106:4176-83.