OMIM: *134850
Gen: FGG
Locus: 4q2

Polymorphismus (FGG 10034C>T)

Thrombin-induced conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in the stabilization of thrombi. A C/T polymorphism at nucleotide 10034 of the fibrinogen gamma gene (FGG 10034C>T) leads to an alteration in the expression of fibrinogen gamma, without affecting total fibrinogen levels. This alteration results in an increased susceptibility to venous thrombosis.

Fibrinogen gamma (FGG 10034C>T) genotypes

Genotype Frequency Commentary
FGG 10034  CC 60% Wild type genotype.
No FGG 10034T variant present detectable.
FGG 10034  CT 35% Heterozygous for the FGG 10034T variant.
The risk for venous thrombosis is about 30% higher compared to the wild type genotype.
FGG 10034  TT 5% Homozygous for the FGG 10034T variant.
The risk of venous thrombosis is increased about 2-fold compared to the wild type genotype.

Indications for testing
Estimation of individual risk for venous thrombosis

  • Grünbacher G et al. The fibrinogen gamma (FGG) 10034C>T polymorphism is associated with venous thrombosis. Thromb Res. 2007;121:33-6.

  • Uitte de Willige S et al. Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen gamma' levels. Blood. 2005;106:4176-83.